Keywords

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 
(E-coli) (1) (yeast) (1) 1 ',4 '-imino tautomer (1)
1 ',4 '-iminothiamin diphospate (1) 1',4'-IMINOPYRIMIDINE TAUTOMER (3) 10-18-PPM RANGE (1)
2-oxo acid decarboxylase (1) 2-oxoacid decarboxylases (1) 2.3 ANGSTROM RESOLUTION (3)
3-DIMENSIONAL STRUCTURE (3) ABSTRACTION (1) ACCELERATION (1)
ACETALDEHYDE (1) ACETOHYDROXYACID SYNTHASE (1) acetoin (3)
acetolactate (1) acetyl CoA (1) acetylmethylphosphinate (1)
acetylphosphinate (1) acetylphosphonate methyl ester (1) ACETYLTRANSFERASE COMPONENT (1)
ACID (4) ACID DECARBOXYLASES (2) ACID-BASE (3)
ACID-BASE GROUPS (8) ACTIVATION (7) active (1)
active site (1) ACTIVE-CENTER (1) ACTIVE-SITE (8)
ACTIVE-SITES (1) ACYLOINS (1) ALDEHYDES (2)
ALDOL REACTIONS (1) ALKALINE PROTEASE INHIBITOR (1) ALKYLATION (1)
allosteric (1) ALPHA-CHYMOTRYPSIN (2) ALPHA-HELIX (1)
alpha-hydroxyethylthiamin diphosphate (1) ALPHA-KETO ESTERS (1) ALPHA-KETOACID DEHYDROGENASE (1)
ALPHA-LYTIC PROTEASE (1) ALZHEIMERS-DISEASE (1) AMIDE-I (1)
AMINO (2) AMINO-ACID-SEQUENCE (1) AMINOPYRIMIDINE RING (2)
AMINOTYROSINE (1) ANALGESIA (1) ANGIOTENSIN CONVERTING ENZYME (1)
ANGSTROM (2) ANGSTROM RESOLUTION (12) ANTIBODY (1)
AQUEOUS-SOLUTION (2) AROMATIC RESIDUES (1) ARYLBORONIC ACIDS (1)
ASPARTATE (4) ASSIGNMENT (1) asymmetry (1)
autoprocessing (1) AZOTOBACTER-VINELANDII (1) BACILLUS-AMYLOLIQUEFACIENS SUBTILISIN (2)
BACILLUS-STEAROTHERMOPHILUS (1) BACILLUS-SUBTILIS (1) BACKBONE CONFORMATIONS (1)
BARRIER HYDROGEN-BOND (1) BASE GROUPS (1) BEHAVIOR (1)
BENZALDEHYDE LYASE (1) BENZOYLFORMATE DECARBOXYLASE (10) beta-hydroxypyruvate (1)
BIFUNCTIONAL ARSENOXIDE (3) BINDING (14) BINDING INHIBITION (1)
BINDING-SITE (2) BINDING-SITES (1) BOUND ENAMINE (3)
BOUND ENAMINE INTERMEDIATE (7) BPN' (2) BRAIN (2)
BREWERS-YEAST (9) BROMOPYRUVATE (1) C(2)-PROTON EXCHANGE (1)
C(ALPHA)-PROTON TRANSFER (1) C-13 (1) C2 (1)
C2 alpha-carbanion or enamine (1) C2 alpha-lactylthiamin (1) carboligase side reactions (1)
CARBON (1) CATALYSIS (23) catalytic triad (1)
CATALYTIC WATER MOLECULE (1) CATALYTIC-TRIAD (1) CATALYZED REACTIONS (2)
CATALYZED-REACTIONS (1) CEREBRAL-CORTEX (1) CHAPERONE (2)
CHEMISTRY (2) CHLORIDE (2) CHYMOTRYPSIN (2)
circular dichroism (3) CIRCULAR-DICHROISM (1) CLONED GENES (2)
COENZYME (4) COFACTOR-BINDING (1) COMPLEX (6)
COMPLEX E1 SUBUNIT (1) COMPLEXES (1) COMPONENT (5)
CONDENSATION (1) CONFORMATION (1) CONFORMATIONAL-CHANGES (1)
COOPERATIVITY (1) COUPLING MODEL (1) coupling of dynamics to catalysis (1)
crystal structure (1) CRYSTAL-STRUCTURE (18) CRYSTAL-STRUCTURES (1)
CRYSTALLOGRAPHIC SNAPSHOTS (1) CRYSTALLOGRAPHY (3) CULTURED SKIN FIBROBLASTS (1)
CYSTEINE-221 (4) CYSTEINES (3) CYTOSOLIC ASPARTATE-AMINOTRANSFERASE (1)
DECARBOXYLASE (7) DECARBOXYLASES (1) DECARBOXYLATIONS (2)
DEFICIENCY (1) DEHYDROGENASE (6) DEHYDROGENASE COMPLEX (4)
DEHYDROGENASE MULTIENZYME COMPLEX (3) DELIVERY (1) DENATURED SUBTILISIN (3)
DEPENDENCE (1) DEPENDENT (4) DEPENDENT ENZYMATIC PATHWAYS (3)
DEPENDENT ENZYME (5) DEPENDENT ENZYMES (3) DERIVATIVES (1)
DIHYDROLIPOAMIDE ACETYLTRANSFERASE (2) DIPHOSPHATE (9) DIPHOSPHATE BINDING (1)
DIPHOSPHATE-DEPENDENT ENZYME (1) DIPHOSPHATE-DEPENDENT ENZYMES (1) diphosphate.Mg(II) (1)
DIRECTED MUTAGENESIS (1) DISULFIDE BOND (1) DOMAIN (1)
DORSAL-ROOT (1) E1 SUBUNIT (5) EGG-WHITE LYSOZYME (1)
EGLIN-C (1) ELASTASE (1) ELECTROCHEMICAL OXIDATION (1)
ELECTRON-RICH (1) ELECTROPHORETIC TRANSFER (1) ENAMINE INTERMEDIATE (2)
enantiomeric excess (1) ENDOPEPTIDASE (1) ENOL ETHER (1)
ENZYMATIC CATALYSIS (1) enzymatic chiral (1) ENZYMATIC PATHWAYS (3)
ENZYMATIC-REACTIONS (1) ENZYME (6) ENZYME ACTION (2)
ENZYME CATALYSIS (1) enzyme model (1) ENZYME PYRUVATE DECARBOXYLASE (1)
ENZYME PYRUVATE OXIDASE (1) ENZYME-LINKED (1) ENZYMES (10)
EPR (1) EQUILIBRIUM ACIDITIES (2) Escherichia coli (1)
Escherichia coli pyruvate (1) ESCHERICHIA-COLI (23) ESCHERICHIA-COLI-K12 (2)
EXCITONIC (1) EXPRESSION (4) FATE (1)
FEMALE RAT (1) FERREDOXIN OXIDOREDUCTASE (1) FLUORESCENCE (2)
FOLD (1) FORCE-FIELD (1) FREE-RADICAL (1)
FUNCTIONAL-ANALYSIS (1) GABA (1) GABA RELEASE (1)
GAMMA-AMINOBUTYRIC ACID (1) GANGLIA (1) GENE (3)
gene expression (1) GENERAL ACID CATALYSIS (1) GLUTAMATE (1)
GLYCINE (1) GLYCINE RECEPTOR IMMUNOREACTIVITY (1) glycolysis (1)
GROUP (1) GROUPS (1) H-1 (1)
H-1 RESONANCES (1) H-1-NMR (1) HETERONUCLEAR (1)
HIGH-LEVEL EXPRESSION (1) His-tag (1) HISTIDINE-RESIDUES (1)
human pyruvate dehydrogenase complex (1) HUMAN PYRUVATE-DEHYDROGENASE (2) HYDROGEN-BOND (2)
HYDROLYSIS (1) IMMUNOSORBENT ASSAY (1) INACTIVATION (5)
INFLUENZA-A (1) INFORMATION-TRANSFER (5) inhibition (5)
INHIBITORS (2) INTERMEDIATE (8) intramolecular (1)
intramolecular folding (1) INTRATHECAL SPACE (1) INVITRO (2)
ION-PAIR (1) IONIZATION (1) ISOLATED THIAMIN YLIDE (1)
ISOMERASE (1) KDO (1) KETO ACIDS (1)
KEY (1) KEY INTERMEDIATE (7) KINETICS (3)
LEVEL EXPRESSION (1) LIBRARY (1) LINKAGE (1)
LIPOAMIDE (1) LIPOAMIDE DEHYDROGENASE (4) LIPOIC ACID (1)
LIPOYL DOMAIN (1) LIPOYL DOMAINS (3) LYSOZYME (1)
MECHANISM (13) mechanism-based (1) MECHANISMS (2)
MEMBRANE TRANSPORT (1) mobile loop dynamics (1) MODEL (3)
MODELS (1) MOLECULAR-CLONING (1) MONOCLONAL (1)
MONOCLONAL-ANTIBODIES (1) MOTIF (1) MULTI-ENZYME COMPLEX (2)
MULTIENZYME COMPLEX (8) MULTIENZYME COMPLEXES (6) MUTAGENESIS (3)
N-15 (3) NEGATIVE (1) NEURONS (2)
NITROCELLULOSE (1) NITROTYROSINE (1) NITROTYROSYL (1)
NITROTYROSYL RIBONUCLEASE-A (1) NMR (2) NMR CHARACTERIZATION (1)
NMR, N-15- (1) NMR-SPECTRA (1) NMR-SPECTROSCOPY (5)
NOCICEPTION (1) NONPERFECT SYNCHRONIZATION (1) NUCLEAR MAGNETIC-RESONANCE (2)
NUCLEAR-MAGNETIC-RESONANCE (2) NUCLEOTIDE-SEQUENCE (8) NUCLEOTIDES (1)
OLEFINS (1) OVERLAP (1) OXIDASE (2)
OXIDATION (2) PANCREATIC ELASTASE (1) PAPAIN (2)
PATHWAYS (2) PDC1 (2) PDC6 (1)
PEPTIDE (1) PEPTIDEBORONIC ACIDS (1) PH (1)
PHOSPHONATE (1) POLYACRYLAMIDE GELS (1) POLYCLONAL ANTIBODY (1)
POLYMERASE (2) POLYPROLINE-II STRUCTURE (1) PORCINE (1)
POTASSIUM STIMULATION (1) POTENTIALS (1) PREDICTION (1)
PRIMARY CULTURE (1) PRO-PEPTIDE (1) PRO-SEQUENCE (3)
PROPERTIES (1) prosubtilisin E (1) PROTEIN (5)
PROTEIN CRYSTAL-STRUCTURES (1) protein dielectric constant (1) PROTEINS (5)
PROTON-TRANSFER (1) PROTON-TRANSFER REACTION (1) PSEUDOMONAS-FLUORESCENS (1)
PYROPHOSPHATE (6) PYROPHOSPHATE ENZYMES (1) PYRUVATE (2)
PYRUVATE DECARBOXYLASE (7) pyruvate dehydrogenase (4) PYRUVATE DEHYDROGENASE COMPLEX (1)
pyruvate dehydrogenase E1 subunit (1) PYRUVATE OXIDASE (1) PYRUVATE-DEHYDROGENASE (1)
PYRUVATE-DEHYDROGENASE COMPLEX (1) RADIOIMMUNOASSAY (1) RAT-BRAIN (1)
REACTION INTERMEDIATE (1) REACTIVITY (3) REARRANGEMENTS (1)
REDUCTIVE ACETYLATION (4) REFINEMENT (1) REGION (1)
REGIONAL SUPERFUSION (1) REGULATORY (1) RELAXATION (1)
RELEVANT (1) RENATURATION (1) RESIDUE (1)
RESIDUES (3) RESOLUTION (21) RIBONUCLEASE-A (1)
RING (1) RNA-POLYMERASE (1) S-SI (1)
SACCHAROMYCES-CEREVISIAE (7) SALT (1) SCATTERING (1)
SECONDARY-STRUCTURE (1) SECRETION (1) SEQUENCE (3)
serine protease (1) SERINE PROTEASES (4) SERINE-PROTEASE (1)
SIDE-CHAIN ENTROPY (1) SITE (6) SITE-DIRECTED (1)
SITE-DIRECTED MUTAGENESIS (6) SITES (1) SKIN (1)
SKIN PERMEATION (1) SLOW-BINDING (1) SOLID-PHASE SYNTHESIS (1)
SOLVENT (1) SPECIFICITY (1) SPECTROSCOPY (1)
SPINAL-CORD (1) STATE (1) STREPTOMYCES-ALBOGRISEOLUS S-3253 (1)
STRIATAL (1) STRUCTURAL BASIS (1) STRUCTURE COMPARISON (1)
STRUCTURE REACTIVITY CORRELATIONS (1) SUBSTITUTIONS (2) SUBSTRATE (6)
SUBSTRATE ACTIVATION (10) SUBSTRATE-ACTIVATION SITE (1) SUBSTRATE-BINDING (1)
SUBTILISIN (2) SUBTILISIN BPN' (1) SUBUNIT (3)
SUICIDE (1) SUICIDE SUBSTRATE (5) SUPPRESSION (1)
SURFACE-PLASMON RESONANCE (1) SYK KINASE (1) synthesis (1)
TAURINE (1) TAUTOMERIC FORM (3) TETRANITROMETHANE (1)
THIAMIN (5) thiamin 2-thiothiazolone diphosphate (1) THIAMIN DIPHOSPHATE (19)
THIAMINE-DEPENDENT ENZYMES (1) THIAZOLIUM C(2)-PROTON EXCHANGE (1) THIAZOLONE DIPHOSPHATE (1)
thiolsubtilisin (1) TITRATION CURVES (1) TRANSCARBAMOYLASE (1)
TRANSDERMAL (1) TRANSIENT (1) TRANSITION-STATE ANALOGS (3)
TRANSKETOLASE (10) TRIAD (1) TRIHYDRATE (1)
TRYPSIN (1) TWO-DIMENSIONAL NMR (1) UNFOLDED STATES (1)
VAGINAL STIMULATION (1) VAGINOCERVICAL STIMULATION (1) VIP (1)
VIRUS (1) WATER (1) WHEAT-GERM (1)
X-ray structure (1) YEAST (3) YEAST PYRUVATE DECARBOXYLASE (11)
YEAST PYRUVATE-DECARBOXYLASE (2) YEAST TRANSKETOLASE (1) ylide/C2-carbanion (1)
ZWITTERION (1) zwitterionic intermediate (1) ZYMOMONAS-MOBILIS (9)